![]() ![]() The development of portal hypertension is a hallmark of LC. Consequently, disruption of the liver architecture due to liver fibrosis and/or cirrhosis causes hemodynamic instability and portal hypertension. Histologically, regenerative nodules with fibrous tissues form in response to chronic injury and lead to LC. Liver cirrhosis (LC) is defined as an advanced stage of liver fibrosis with distortion of the hepatic vasculature and architecture. The excess deposition of the ECM changes the normal architecture of the liver resulting in pathophysiologic damage to the organ. Deposition of excess extracellular matrix (ECM) that is rich in fibril-forming collagens is a typical finding of liver fibrosis. Liver fibrosis is a histological consequence of the wound-healing process resulting from chronic liver diseases such as viral hepatitis, alcoholic liver disease, non-alcoholic fatty liver disease, and other liver disorders. Liver fibrosis is one of the leading causes of mortality because it changes the architecture of certain organs and disrupts normal function. Therefore, the HVPG measurement can be used to monitor areas the chronic liver disease but also other important areas of chronic liver disease. The HVPG measurement has been used clinically for fibrosis diagnosis, risk stratification, preoperative screening for liver resection, monitoring the efficacy of medical treatments, and assessing the prognosis of liver fibrosis. Hepatic venous pressure gradient (HVPG) measurement has been known as a modality to evaluate the portal pressure. Recent evidences suggested that histologic, clinical, hemodynamic, and biologic features are closely associated in patients with chronic liver disease. Although liver biopsy is a gold standard for assessing the stage of liver fibrosis, it may not completely represent the stage of liver fibrosis because of sampling error or semi-quantative measurement. Currently, liver fibrosis has been known as a reversible dynamic process in previous literatures. Liver fibrosis is a common histological change of chronic liver injury and it is closely related with portal hypertension which is hemodynamic complication of chronic liver disease. ![]()
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